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On April 28, 2020, Alfa Chemistry announced to have integrated its supply of boronic compound products to its customers worldwide, which include borate, boro-amino acids, boronic acids, boronic esters, bromine series as well as others.   Structurally speaking, a boronic acid is a compound related to…
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Yesterday · From Emmaffv
Recently, scientists found that when AI is used to predict protein-ligand interactions, the commonly used training sets (PDBbind and DUD-E) have serious data bias for AI model training, resulting in artificially high AI models. The prediction lacks generalization ability and robustness, misleads the…
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13 Days Ago · From Emmaffv
Another area involved in single-cell genome research is the study of various human recombination patterns. The so-called recombination refers to the process in which two large chromosomal fragments inherited from the paternal and maternal lines in sperm cells and egg cells are broken, and then conne…
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14 Days Ago · From Emmaffv
Recently, researchers from Ghent University Hospital in Belgium published an article entitled "A human immune dysfunction syndrome characterized by severe hyperinflammation with a homozygous nonsense roquin-1 mutation" in Nature Communications. By studying a case of hyperinflammatory syndrome with a…
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15 Days Ago · From Emmaffv
Abstract: Since SARS-CoV-2 is similar to SARS-CoV, the research of 2003 that ACE2 is an essential receptor for SARS-CoV infection can be further explored for unveiling the secret of SARS-CoV-2. An ongoing outbreak of a novel coronavirus (SARS-CoV-2) has raised global concerns. It is identified as th…
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16 Days Ago · From Emmaffv
According to reports, the rapid spread of COVID-19 has led to a surge in the number of suspected infections and close contacts. The early detection of the virus can not only enable the infected person to be treated in time and reduce the risk of death, but also can effectively control the source of …
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18 Days Ago · From Emmaffv
Recently, a team led by the University of Bonn discovered how TLR8 plays an important role in defending human cells against invaders. It was found that when RNaseT2 and RNase2 cut the ribonucleic acid (RNA) of bacteria into small fragments with fingerprint characteristics, they were able to be recog…
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19 Days Ago · From Emmaffv
Coronaviruses were once taken as a group of pathogens that cause no or slight self-healing diseases in humans, which, however, have ignited several worldwide prevalences in the first 20 years of the 21st century, that is, severe acute respiratory syndrome in 2002-2003, Middle East respiratory syndro…
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20 Days Ago · From Emmaffv
DNA methylation is a form of chemical modification of DNA that can change genetic performance without changing the DNA sequence. The so-called DNA methylation refers to the covalent bonding of a methyl group at the 5 'carbon position of the cytosine of the genomic CpG dinucleotide under the action o…
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21 Days Ago · From Emmaffv
The biggest difficulty in single-cell sequencing is that the amplification efficiency of some DNA fragments is much higher than that of others. Xie et al. invented a new multiple annealing and looping-based amplification cycles (MALBAC) in 2012. This technology first requires 5 rounds of MDA pre-amp…
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43 Days Ago · From Emmaffv
T cells are a key component of our immune system and play a key role in protecting us from harmful pathogens such as viruses and bacteria, as well as cancer. The more we know about how they recognize, act on, or even kill infected cells or cancer cells, the closer we can get to developing drugs and …
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44 Days Ago · From Emmaffv
With the global pandemic of novel coronavirus (2019-nCoV) pneumonia raging, most countries in the world have already entered strict control. Before the vaccine has been fully developed, the best way for a country to control the epidemic is to urge people not to go out and stay at home to cut off the…
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46 Days Ago · From Emmaffv
Immunoglobulin E (IgE) As mentioned above, IgE plays an important role in the asthma inflammatory response pathway, especially for the onset of allergic asthma. In 2003, Novartis' IgE antibody, omalizumab (trade name Xolair) entered the market as the first antibody drug against asthma, marking the o…
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47 Days Ago · From Emmaffv
Statins, currently commonly used as lipid-lowering drugs and anti-atherosclerotic drugs, plays an important role in the prevention of cardiovascular and cerebrovascular diseases. Common statins include lovastatin, fluvastatin, pravastatin, simvastatin, atorvastatin, and rosuvastatin, each of which h…
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48 Days Ago · From Emmaffv
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